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Thermo Fisher Scientific
Thermo Fisher Scientific HPLC Column SurePac Oligo RP MDi HPLC Column, 2.5 μm, 2.1 x 20 mm
Thermo Scientific™ SurePac™ Oligo RP MDi™ HPLC columns deliver high-resolution, reproducible separations for therapeutic oligonucleotides and nucleic acids across R and D and QC workflows. Built on monodisperse, supermacroporous polymeric packing with bio-inert hardware, they provide stable performance even under elevated pH and temperature conditions, resolving truncation impurities while supporting large oligos and intact nucleic acids for scalable LC-MS and LC-UV analysis. Purpose-built for oligonucleotide RP separations Optimized for DNA and RNA oligonucleotides, including modified sequences, delivering consistent retention and selectivity across short and long oligos. Bioinert, metal-free fluid path Reduces metal/oligonucleotide interactions to improve recovery, minimize adsorption, and deliver cleaner peak shapes for sensitive analyses. Optimized for ion-pair RP LC-MS Fully compatible with common ion-pairing reagents such as HFIP/Meer tonen
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